Chronic Cholestatic Liver Injury Attributable to Vedolizumab
نویسندگان
چکیده
Drug-induced liver injury is a rare but clinically important diagnosis. Vedolizumab is an α4β7 integrin inhibitor recently approved for use in patients with moderate-to-severe inflammatory bowel disease. Cases of hepatoxicity due to vedolizumab in the pre-marketing stage were rare, and all cases resolved upon drug withdrawal. We present here the first reported case of hepatotoxicity attributable to vedolizumab, which despite drug cessation persisted with chronic cholestatic liver injury.
منابع مشابه
Nod2 deficiency protects mice from cholestatic liver disease by increasing renal excretion of bile acids.
BACKGROUND & AIMS Chronic liver disease is characterized by fibrosis that may progress to cirrhosis. Nucleotide oligomerization domain 2 (Nod2), a member of the Nod-like receptor (NLR) family of intracellular immune receptors, plays an important role in the defense against bacterial infection through binding to the ligand muramyl dipeptide (MDP). Here, we investigated the role of Nod2 in the de...
متن کاملVedolizumab: a novel medical intervention in the treatment of primary sclerosing cholangitis.
Westerveld D, et al. BMJ Case Rep 2017. doi:10.1136/bcr-2017-220351 Description Primary sclerosing cholangitis (PSC) is an idiopathic and insidious cholestatic liver disease characterised by persistent inflammation of the biliary tree, leading to fibrosis and stricturing. Often associated with inflammatory bowel disease, pathogenesis may be related to activated intestinal T-cells expressing the...
متن کاملHepatoprotective and Antioxidative Effect of Rosmarinic Acid Against Bile Duct Ligated (BDL)-Induced Cholestatic in Male Rats
Aims: Cholestasis is a type of liver disease due to structural damage and dysfunction of hepatobiliary system which at first, results in accumulation of bile acids and other toxins in plasma and hepatic tissue. The aim of the current study was to investigate the possible hepatoprotective effects of rosmarinic acid against oxidative stress and liver injury in bile duct ligation (BDL)- induced ch...
متن کاملProtective Effects of Guava Pulp on Cholestatic Liver Injury
Background. Cholestatic liver injury is a leading cause of chronic liver diseases involved with oxidative stress changes and inflammation; thus, antioxidant and anti-inflammation compound-rich guava may play a pivotal role in protecting against the cholestatic liver damages. Our aims for this study are to determine whether guava pulp (GP) has protective effects on cholestatic liver injury-induc...
متن کاملHeparin-binding epidermal growth factor-like growth factor and hepatocyte growth factor inhibit cholestatic liver injury in mice through different mechanisms
In contrast to hepatocyte growth factor (HGF), the therapeutic potential and pathophysiologic roles of heparin-binding epidermal growth factor-like growth factor (HB-EGF) in liver diseases remain relatively unknown. To address the lack of effective pharmacologic treatments for cholestatic liver injuries, as well as to clarify the biologic features of these growth factors, we explored the effect...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2016